A New Coordination Polymer for Effective 5-fluorouracil Loading and Anti-lung Cancer Activity Study

Resumo

A new three-dimensional porous coordination polymer with the formula of [Ba(HTATB)-(H₂O)](DMF)₂ (I) has been solvothermally synthesized from 4,4′,4″-s-triazine-2,4,6-triyltribenzoic acid (H₃TATB) and Ba(NO₃)₂ under DMF media and characterized by single crystal X-ray diffraction (CIF file CCDC no. 1856562) and elemental analysis. The efficient encapsulation of an anticancer drug 5-fluorouracil (5-FU) on the desolvated I (Ia) has been studied both experimentally and computationally. In addition, in vitro anti-lung cancer activity of compounds I and 5-FU loaded 1a have also been evaluated using MTT assay.