Email this article A New Coordination Polymer for Effective 5-fluorouracil Loading and Anti-lung Cancer Activity Study
- Authors: Shi L.Y.1, Zhang W.2, Zhou G.Z.3, Cao Q.2
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Affiliations:
- Department of Respiratory and Critical Care Medicine, Affiliated Baoji Hospital of Xi’an Medical University
- The Affiliated Hospital of Yan’An University
- Respiratory Department of Ankang Traditional Chinese Medicine Hospital
- Issue: Vol 45, No 11 (2019)
- Pages: 817-823
- Section: Article
- URL: https://journals.rcsi.science/1070-3284/article/view/214932
- DOI: https://doi.org/10.1134/S1070328419110083
- ID: 214932
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Abstract
A new three-dimensional porous coordination polymer with the formula of [Ba(HTATB)-(H2O)](DMF)2 (I) has been solvothermally synthesized from 4,4′,4″-s-triazine-2,4,6-triyltribenzoic acid (H3TATB) and Ba(NO3)2 under DMF media and characterized by single crystal X-ray diffraction (CIF file CCDC no. 1856562) and elemental analysis. The efficient encapsulation of an anticancer drug 5-fluorouracil (5-FU) on the desolvated I (Ia) has been studied both experimentally and computationally. In addition, in vitro anti-lung cancer activity of compounds I and 5-FU loaded 1a have also been evaluated using MTT assay.
About the authors
L. Y. Shi
Department of Respiratory and Critical Care Medicine, Affiliated Baoji Hospital of Xi’an Medical University
Email: qiang_cao666@aliyun.com
China, Baoji, Shaanxi
W. Zhang
The Affiliated Hospital of Yan’An University
Email: qiang_cao666@aliyun.com
China, Yan’An, Shaanxi
G. Z. Zhou
Respiratory Department of Ankang Traditional Chinese Medicine Hospital
Email: qiang_cao666@aliyun.com
China, Ankang, Shaanxi
Q. Cao
The Affiliated Hospital of Yan’An University
Author for correspondence.
Email: qiang_cao666@aliyun.com
China, Yan’An, Shaanxi
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