Antioxidant status in albino rats vaccinated against salmonellosis under chronic action of T-2 toxin and its correction by aminoseleton

Abstract

The article represents the study of the effect of chronic intoxication with T-2 toxin on the antioxidant status of albino rats under their vaccination against salmonellosis. It is stated that the intensity of lipid peroxidation (LPO) processes increased under the action of toxin and led to increased content of toxic product, malonic dialdehyde (MDA), in blood and decreased indices of antioxidant protection (AOP), activity of glutathione peroxidase (GPO) and catalase enzymes and level of vitamins E and A, in liver and nitric oxide in blood serum. The application of aminoseleton promoted the lower level of LPO, decreased MDA in blood, and increased potential of enzymatic and nonenzymatic components of AOP.