Protective properties of attenuated strains of the african swine fever virus in the course of immunodeficiency induced by radiation

Abstract

Introduction of the FC-135 strain of an attenuated African swine fever (ASF) virus to immunodeficient swine did not cause clinical signs of the disease and protected them against the virulent strain France- 32. However, inoculation of an attenuated strain MC-200 was the cause of death from ASF of approximately half of animals with immunodeficiency and provided partial protection from further infection with the virulent strain Mozambique-78. Since reversions of virulent properties of the MC-200 strain have not been registered, the cause of death of pigs inoculated with the strain is the development of ASF against the background of immunodeficiency induced by radiation.