Concentration of nitrite and nonthiol nitroso compounds in tissues as a high sensitive marker of leukocyte activity

V. Yu. Titov; V. G. Vertiprakhov; O. V. Kosenko; V. I. Fisinin; M. E. Dmitrieva; O. B. Novikova; V. A. Petrov

doi:10.3103/S1068367417050196

Concentration of nitrite and nonthiol nitroso compounds in tissues as a high sensitive marker of leukocyte activity

Authors: Titov V.Y.¹, Vertiprakhov V.G.¹, Kosenko O.V.¹, Fisinin V.I.¹, Dmitrieva M.E.², Novikova O.B.², Petrov V.A.³
Affiliations:
1. All-Russia Scientific Research and Technological Institute of Poultry Breeding
2. All-Russia Scientific Research Veterinary Institute of Poultry Breeding
3. Russian National Research Medical University
Issue: Vol 43, No 5 (2017)
Pages: 423-426
Section: Animal Husbandry
URL: https://journals.rcsi.science/1068-3674/article/view/230168
DOI: https://doi.org/10.3103/S1068367417050196
ID: 230168

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

This paper shows that the inflammation-induced appearance of nitrite and nonthiol nitroso compounds in the hen blood and cow milk is due to oxidation of dinitrosyl iron complexes (DNIC) and nitrosothiols (RSNO) by reactive oxygen species (ROS), which are produced by activated leukocytes. Since DNIC and RSNO are highly effective ROS scavengers, the content of nitrite and nonthiol nitroso compounds can be regarded as one of the most sensitive indicators of leukocyte activation.