Effect of ligands binding on the isotherm of hybridization of the DNA-chip
- Авторлар: Tsaturyan H.L.1, Tonoyan S.A.1, Morozov V.F.1, Mamasakhlisov Y.S.1
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Мекемелер:
- Yerevan State University
- Шығарылым: Том 52, № 2 (2017)
- Беттер: 180-188
- Бөлім: Article
- URL: https://journals.rcsi.science/1068-3372/article/view/228381
- DOI: https://doi.org/10.3103/S106833721702013X
- ID: 228381
Дәйексөз келтіру
Аннотация
The factors are analyzed, which influence both the hybridization thermodynamics and the DNA/DNA-duplex stability. The non-competitive hybridization of the DNA as well as the competitive hybridization on the surface are investigated. It is shown that the binding to the intercalating ligands results to an increase in the selectivity and sensitivity of the DNA chips.
Негізгі сөздер
Авторлар туралы
H. Tsaturyan
Yerevan State University
Email: y.mamasakhlisov@ysu.am
Армения, Yerevan
Sh. Tonoyan
Yerevan State University
Email: y.mamasakhlisov@ysu.am
Армения, Yerevan
V. Morozov
Yerevan State University
Email: y.mamasakhlisov@ysu.am
Армения, Yerevan
Y. Mamasakhlisov
Yerevan State University
Хат алмасуға жауапты Автор.
Email: y.mamasakhlisov@ysu.am
Армения, Yerevan
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