Platinum Polyoxoniobates Form Adducts with DNA
- 作者: Yudkina A.1,2, Sokolov M.3, Abramov P.3, Grin I.1,2, Zharkov D.1,2
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隶属关系:
- Institute of Chemical Biology and Fundamental Medicine
- Novosibirsk State University
- Nikolaev Institute of Inorganic Chemistry
- 期: 卷 45, 编号 6 (2019)
- 页面: 641-646
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229280
- DOI: https://doi.org/10.1134/S1068162019060414
- ID: 229280
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详细
Platinum complexes are among the most commonly prescribed drugs in cancer therapy but show significant toxicity to healthy tissues as a side effect. Platinum polyoxometalates are platinum complexes liganded with cluster anions consisting of oxygen atoms and transition metals. Their properties related to a potential use as anticancer drugs have never been studied. In this paper, we have investigated the effect of platinum (IV) polyoxoniobate of the [Nb6O19{Pt(OH)2}]2 structure containing two platinum centers and two polynuclear Lindqvist type anions on the activity of a number of DNA polymerases belonging to different families (Klenow fragment of Escherichia coli DNA polymerase I, bacteriophage RB69 DNA polymerase, human DNA polymerases β and κ, DNA polymerase IV from Sulfolobus solfataricus). On its own, platinum polyoxoniobate did not act as an inhibitor of DNA polymerases, but was capable of forming adducts with DNA.
作者简介
A. V. Yudkina
Institute of Chemical Biology and Fundamental Medicine; Novosibirsk State University
Email: dzharkov@niboch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
M. N. Sokolov
Nikolaev Institute of Inorganic Chemistry
Email: dzharkov@niboch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090
P. A. Abramov
Nikolaev Institute of Inorganic Chemistry
Email: dzharkov@niboch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090
I. R. Grin
Institute of Chemical Biology and Fundamental Medicine; Novosibirsk State University
Email: dzharkov@niboch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
D. O. Zharkov
Institute of Chemical Biology and Fundamental Medicine; Novosibirsk State University
编辑信件的主要联系方式.
Email: dzharkov@niboch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090