Platinum-Based Antitumor Drugs and Their Liposomal Formulations in Clinical Trials
- 作者: Arantseva D.1, Vodovozova E.2
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隶属关系:
- Drugs Technology Ltd.
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- 期: 卷 44, 编号 6 (2018)
- 页面: 619-630
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229041
- DOI: https://doi.org/10.1134/S1068162018060031
- ID: 229041
如何引用文章
详细
Platinum-based antitumor drugs are the most common drugs in modern oncology practice. They are used for the treatment of a large number of malignant tumors of different etiology. However, their low specificity and high systemic toxicity significantly reduce the efficacy of chemotherapy. With the goal of improving pharmacological properties of platinum-based drugs, an intense search for supramolecular drug delivery systems is being carried out in many laboratories. This review focuses on liposomal drugs, which are currently at different stages of clinical trials. In the first part of the review we described modern concepts on the action of Pt-based drugs. Information about the drugs used in clinical practice as well as data about some new promising compounds is also provided. Also, justification of the rationale for the creation of liposomal drug delivery systems is given, and six Pt-containing liposomal formulations under clinical trials are reviewed, including the published data on the composition, how they act, and the results of preclinical and clinical trials. Several examples of new Pt-based liposomal formulations are given. The prospects of the liposomal platform development for platinum-based drugs are discussed.
作者简介
D. Arantseva
Drugs Technology Ltd.
Email: elvod@lipids.ibch.ru
俄罗斯联邦, Мoscow, 141400
E. Vodovozova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
编辑信件的主要联系方式.
Email: elvod@lipids.ibch.ru
俄罗斯联邦, Moscow, 117997