Synthesis of Amides of Carboxylic Acids with an Imide and Alicyclic Fragments and a Study of Their Genotoxic Activity in the Allium Test
- Авторы: Firstova A.1, Kofanov E.1, Zakshevskaya V.1, Kovaleva M.2
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Учреждения:
- Yaroslavl State Technical University
- Demidov Yaroslavl State University
- Выпуск: Том 45, № 3 (2019)
- Страницы: 204-213
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229194
- DOI: https://doi.org/10.1134/S1068162019030026
- ID: 229194
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Аннотация
A method for the high-yield synthesis of several amides of carboxylic acids containing an imide, a cyclohexene, and a norbornene cycle as well as fragments of natural amino acids has been developed. The compounds synthesized have been tested for mutagenic activity on plant objects using the Allium test. It has been shown that the presence of a nitro group endows the compound with inhibitory property and the capacity to induce chromosomal rearrangements, whereas the presence of an aliphatic carbon chain, a methyl group, and a morpholine fragment, on the contrary, confers growth-regulating properties without inducing the mutagenic effect. The study has confirmed that the resulting biologically active compounds are of interest for practical implementation in agriculture.
Об авторах
A. Firstova
Yaroslavl State Technical University
Автор, ответственный за переписку.
Email: firstova.a.a@mail.ru
Россия, Yaroslavl, 150001
E. Kofanov
Yaroslavl State Technical University
Email: firstova.a.a@mail.ru
Россия, Yaroslavl, 150001
V. Zakshevskaya
Yaroslavl State Technical University
Email: firstova.a.a@mail.ru
Россия, Yaroslavl, 150001
M. Kovaleva
Demidov Yaroslavl State University
Email: firstova.a.a@mail.ru
Россия, Yaroslavl, 150003