The Role of Intercellular Communication in Cancer Progression
- Авторы: Shender V.1,2, Arapidi G.1,2,3, Pavlyukov M.1, Shnaider P.1,2, Anufrieva K.1,2, Stepanov G.4, Govorun V.1,2,3
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Учреждения:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Federal Research and Clinical Center of Physical–Chemical Medicine
- Moscow Institute of Physics and Technology
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
- Выпуск: Том 44, № 5 (2018)
- Страницы: 473-480
- Раздел: Review Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228999
- DOI: https://doi.org/10.1134/S1068162018040179
- ID: 228999
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Аннотация
Although understanding of the molecular biology of cancer has advanced and medicine has an impressive arsenal of chemotherapeutic drugs, the problem of tumor resistance to individual drugs and drug combinations has not yet been resolved. Known mechanisms of cancer chemoresistance do not explain the reason for such a phenomenon as “apoptosis-induced proliferation,” where cells dying under the effect of the therapy secrete some signaling molecules into the extracellular medium to promote proliferation, survival, and acquisition of a more aggressive phenotype of neighboring cancer cells. The nature of this unexpected phenomenon is only now beginning to be partially clarified, but the nature of such signaling between apoptotic cancer cells and their neighboring cells remains largely unknown. For this reason, in this review we discuss currently known types of intercellular communication of tumor cells, give specific examples of important secreted molecules involved in signaling between cancer cells, and describe possible cell interactions contributing to the progress of cancer outgrowth.
Об авторах
V. Shender
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Federal Research and Clinical Center of Physical–Chemical Medicine
Автор, ответственный за переписку.
Email: shender_vika@mail.ru
Россия, Moscow, 119779; Moscow, 119435
G. Arapidi
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Federal Research and Clinical Center of Physical–Chemical Medicine; Moscow Institute of Physics and Technology
Email: shender_vika@mail.ru
Россия, Moscow, 119779; Moscow, 119435; Dolgoprudnyi, 141701
M. Pavlyukov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: shender_vika@mail.ru
Россия, Moscow, 119779
P. Shnaider
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Federal Research and Clinical Center of Physical–Chemical Medicine
Email: shender_vika@mail.ru
Россия, Moscow, 119779; Moscow, 119435
K. Anufrieva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Federal Research and Clinical Center of Physical–Chemical Medicine
Email: shender_vika@mail.ru
Россия, Moscow, 119779; Moscow, 119435
G. Stepanov
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: shender_vika@mail.ru
Россия, Novosibirsk, 630090
V. Govorun
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Federal Research and Clinical Center of Physical–Chemical Medicine; Moscow Institute of Physics and Technology
Email: shender_vika@mail.ru
Россия, Moscow, 119779; Moscow, 119435; Dolgoprudnyi, 141701