Отправить статью по E-mail Results of phase I clinical trials of a combined vaccine against HIV-1 based on synthetic polyepitope immunogens
- Авторы: Karpenko L.1, Bazhan S.1, Bogryantseva M.1, Ryndyuk N.2, Ginko Z.2, Kuzubov V.2, Lebedev L.1, Kaplina O.1, Reguzova A.1, Ryzhikov A.1, Usova S.1, Oreshkova S.1, Nechaeva E.1, Danilenko E.1, Ilyichev A.1
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Учреждения:
- Vector State Research Center of Virology and Biotechnology, Koltsovo
- 163 Medical Unit of the Federal Medical and Biological Agency of Russia, Koltsovo
- Выпуск: Том 42, № 2 (2016)
- Страницы: 170-182
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/227869
- DOI: https://doi.org/10.1134/S1068162016020060
- ID: 227869
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Аннотация
The CombiHIVvac candidate vaccine against HIV-1/AIDS containing two synthetic polyepitope immunogens such as TBI and TCI to stimulate the humoral and cellular response is described. The recombinant TBI protein is constructed as a polypeptide with predetermined tertiary structure and contains epitopes of Env and Gag proteins of HIV-1. TCI contains CD8+ CTL and CD4+ Th epitopes of the major viral proteins such as Env, Gag, Pol and Nef which are highly conserved among subtypes A, B and C of HIV-1. A gene encoding the polyepitope TCI immunogen is inserted into a pcDNA-3.1 plasmid vector. The CombiHIVvac vaccine was designed as virus-like particles containing the pcDNA-TCI plasmid in their cores (DNA vaccine) and the TBI protein conjugated with polyglucin on their surfaces. Immunogenicity and safety of CombiHIVvac has been shown in preclinical studies in several animal species. Phase I clinical trials of the vaccine have been completed and the results obtained in human volunteers confirmed that the CombiHIVvac candidate vaccine was safe and did not cause side effects, at the same time, inducing the HIV-specific humoral and cellular immune response. The phase II clinical trials have been approved by the Ministry of Health and Social Development of the Russian Federation.
Об авторах
L. Karpenko
Vector State Research Center of Virology and Biotechnology, Koltsovo
Автор, ответственный за переписку.
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
S. Bazhan
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
M. Bogryantseva
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
N. Ryndyuk
163 Medical Unit of the Federal Medical and Biological Agency of Russia, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
Z. Ginko
163 Medical Unit of the Federal Medical and Biological Agency of Russia, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
V. Kuzubov
163 Medical Unit of the Federal Medical and Biological Agency of Russia, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
L. Lebedev
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
O. Kaplina
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
A. Reguzova
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
A. Ryzhikov
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
S. Usova
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
S. Oreshkova
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
E. Nechaeva
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
E. Danilenko
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
A. Ilyichev
Vector State Research Center of Virology and Biotechnology, Koltsovo
Email: karpenko@vector.nsc.ru
Россия, Novosibirsk oblast, 630559
