Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules
- Autores: Fatih Yılmaz 1, Menteşe E.2, Baltaş N.2
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Afiliações:
- Vocational School of Technical Studies, Department of Chemistry and Chemical Processing Technology, Recep Tayyip Erdogan University
- Department of Chemistry, Faculty of Arts and Sciences, Recep Tayyip Erdogan University
- Edição: Volume 45, Nº 6 (2019)
- Páginas: 575-584
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229258
- DOI: https://doi.org/10.1134/S1068162019060402
- ID: 229258
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Resumo
In this study, a new series of succinimide hybrid molecules containing isothiocyanate, coumarin, isatin, and furan moieties was synthesized and screened for α-glucosidase and antioxidant activities. Preliminary results revealed that all molecules showed good α-glucosidase inhibition effectiveness. Antioxidant activities of the hybrid molecules were determined using cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) assays. Also, the radical scavenging activities of the synthesized compounds were assayed by using \({\text{ABT}}{{{\text{S}}}^{{\centerdot {\text{ + }}}}}\) and \({\text{DPP}}{{{\text{H}}}^{\centerdot }}\) methods. The results showed that all compounds exhibited moderated to high scavenging activity.
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Sobre autores
Fatih Yılmaz
Vocational School of Technical Studies, Department of Chemistry and Chemical Processing Technology,Recep Tayyip Erdogan University
Email: emre.mentese@erdogan.edu.tr
Turquia, Rize, 53100
Emre Menteşe
Department of Chemistry, Faculty of Arts and Sciences, Recep Tayyip Erdogan University
Autor responsável pela correspondência
Email: emre.mentese@erdogan.edu.tr
Turquia, Rize, 53100
Nimet Baltaş
Department of Chemistry, Faculty of Arts and Sciences, Recep Tayyip Erdogan University
Email: emre.mentese@erdogan.edu.tr
Turquia, Rize, 53100