Biological activity of usnic acid and its derivatives: Part 2. effects on higher organisms. Molecular and physicochemical aspects

Resumo

Usnic acid (UA) is a commercially available lichen metabolite. Its biological activity is diverse, and it is of interest for pharmacopoeia. The second part of the review is dedicated to the biological action of UA and its derivatives on higher organisms. Effects exhibited by UA at the cellular level and the molecular and physicochemical aspects of its biological activity are considered. Special attention is placed on the possibility of modifying the biological activity of UA by change of its bioavailability or modification of its molecular structure.