Polymethylene Derivatives of Nucleic Bases Bearing ω-Functional Groups: Х. A Novel Approach to the Synthesis of α-Amino-ω-Nucleo Carboxylic Acids
- Авторлар: Komissarov V.1, Kritsyn A.1
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Мекемелер:
- Engelhardt Institute of Molecular Biology
- Шығарылым: Том 44, № 6 (2018)
- Беттер: 705-711
- Бөлім: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229055
- DOI: https://doi.org/10.1134/S1068162018050060
- ID: 229055
Дәйексөз келтіру
Аннотация
A novel approach to the synthesis of α-amino-ω-nucleo carboxylic acids, analogs of willardiin, an activator of the receptor of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid, which is responsible for the transfer of a fast stimulating signal in the synapses of the nervous system of vertebrates, is proposed. Based on substantial differences in the reactivity of halogen atoms in α,ω-dihalogen carboxylic acids, the esters of α-phthaloylimido-ω-chloro carboxylic acids have been synthesized. The alkylation of uracil, thymine, and adenine with these esters gave the key compounds, the esters of α-phthaloylimido-ω-nucleo carboxylic acids. The consecutive removal of the phthalyl protective group and acid hydrolysis led to new polymethylene derivatives of nucleic bases, which are α-amino-ω-nucleo carboxylic acids. The physical and chemical properties of these compounds were studied.
Негізгі сөздер
Авторлар туралы
V. Komissarov
Engelhardt Institute of Molecular Biology
Email: amk@eimb.ru
Ресей, Moscow, 119901
A. Kritsyn
Engelhardt Institute of Molecular Biology
Хат алмасуға жауапты Автор.
Email: amk@eimb.ru
Ресей, Moscow, 119901