Synthesis and Antiproliferative Activity of Conjugates of Anthracycline Antibiotics with Sesquiterpene Lactones of the Elecampane
- Авторлар: Semakov A.1, Anikina L.1, Afanasyeva S.1, Pukhov S.1, Klochkov S.1
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Мекемелер:
- Institute of Physiologically Active Compounds
- Шығарылым: Том 44, № 5 (2018)
- Беттер: 538-546
- Бөлім: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229021
- DOI: https://doi.org/10.1134/S1068162018040167
- ID: 229021
Дәйексөз келтіру
Аннотация
The daunorubicin and doxorubicin anthracycline antibiotics were modified with the Inula helenium L. sesquiterpene lactones (alantolactone, isoalantolactone, and alloalantolactone) and with their epoxy derivatives. Antiproliferative properties of these conjugates were studied on tumor and normal cell lines. The daunorubicin conjugates with the sesquiterpene lactones (isoalantolactone, allantolactone, and alloalantolactone) and with their epoxy derivatives were found to exhibit the higher activity against human tumor cell lines than the corresponding doxorubicin conjugates. The daunorubicin conjugate with epoxyisoalantolactone proved to be the most effective compound, because it was more cytotoxic than daunorubicin towards a number of cell lines, including those daunorubicin-resistant, and did not affect normal human cells.
Негізгі сөздер
Авторлар туралы
A. Semakov
Institute of Physiologically Active Compounds
Хат алмасуға жауапты Автор.
Email: l_vok@list.ru
Ресей, Chernogolovka, 142432
L. Anikina
Institute of Physiologically Active Compounds
Email: l_vok@list.ru
Ресей, Chernogolovka, 142432
S. Afanasyeva
Institute of Physiologically Active Compounds
Email: l_vok@list.ru
Ресей, Chernogolovka, 142432
S. Pukhov
Institute of Physiologically Active Compounds
Email: l_vok@list.ru
Ресей, Chernogolovka, 142432
S. Klochkov
Institute of Physiologically Active Compounds
Email: l_vok@list.ru
Ресей, Chernogolovka, 142432