Email this article Synthesis and Cytotoxicity of Triterpenic Acids Modified at C3 and C28 Positions
- Authors: Khusnutdinova E.F.1, Petrova A.V.1, Kazakova O.B.1, Barmashov A.E.2
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Affiliations:
- Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
- Blokhin National Medical Research Center of Oncology, Ministry of Health, Russian Federation
- Issue: Vol 45, No 6 (2019)
- Pages: 552-557
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229253
- DOI: https://doi.org/10.1134/S1068162019050042
- ID: 229253
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Abstract
Series of N-, S- and Br-derivatives of betulinic, oleanolic, and ursolic acids have been synthesized and screened for their in vitro antitumor activity (cytotoxicity). N-Methylpiperazinylamide of 2-[3-pyridinylidene]-ursolic acid and methyl 2-methylideneureido-betulonate have shown significant cytotoxic activity against the PC3 cancer cells (IC50 = 8 μM) and HCT-116 cell line (IC50 = 5.7 μM).
About the authors
E. F. Khusnutdinova
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Author for correspondence.
Email: ElmaH@inbox.ru
Russian Federation, Ufa, 450054
A. V. Petrova
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: ElmaH@inbox.ru
Russian Federation, Ufa, 450054
O. B. Kazakova
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: ElmaH@inbox.ru
Russian Federation, Ufa, 450054
A. E. Barmashov
Blokhin National Medical Research Center of Oncology, Ministry of Health, Russian Federation
Email: ElmaH@inbox.ru
Russian Federation, Moscow, 115478
