Sorbus aucuparia L. Fruit Is a Source of the Drug for Increasing the Efficiency of Tumor Chemotherapy
- Authors: Isaikina N.V.1, Kalinkina G.I.1, Razina T.G.2, Zueva E.P.2, Rybalkina O.Y.2,3, Ulirich A.V.2, Fedorova E.P.2, Shilova A.B.1
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Affiliations:
- Siberian State Medical University
- Tomsk National Research Medical Center, Russian Academy of Sciences
- National Research Tomsk State University
- Issue: Vol 44, No 7 (2018)
- Pages: 899-905
- Section: Low Molecular Weight Compounds
- URL: https://journals.rcsi.science/1068-1620/article/view/229105
- DOI: https://doi.org/10.1134/S1068162018070038
- ID: 229105
Cite item
Abstract
The composition of phenolic compounds of rowanberry (Sorbus aucuparia L.) fruit extracts prepared with 40% ethanol and 95% acidified ethanol was studied. The differences in the content of flavonoids, including anthocyanins, and phenolic acids were shown. It was found that the antimetastatic activity of cyclophosphamide was most efficiently increased by the rowanberry fruit extract in 95% acidified ethanol enriched in anthocyanins. The aim of the present research was to investigate the effect of hydroalcoholic extracts of rowanberry fruit on the development of Lewis lung carcinoma and the antitumor activity of cyclophosphamide and to reveal the most effective extract containing a phenolic complex for its further study as a promising drug.
About the authors
N. V. Isaikina
Siberian State Medical University
Author for correspondence.
Email: nadezhda.isaykina@gmail.com
Russian Federation, Tomsk, 634050
G. I. Kalinkina
Siberian State Medical University
Email: nadezhda.isaykina@gmail.com
Russian Federation, Tomsk, 634050
T. G. Razina
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: nadezhda.isaykina@gmail.com
Russian Federation, Tomsk, 634028
E. P. Zueva
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: nadezhda.isaykina@gmail.com
Russian Federation, Tomsk, 634028
O. Yu. Rybalkina
Tomsk National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State University
Email: nadezhda.isaykina@gmail.com
Russian Federation, Tomsk, 634028; Tomsk, 634050
A. V. Ulirich
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: nadezhda.isaykina@gmail.com
Russian Federation, Tomsk, 634028
E. P. Fedorova
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: nadezhda.isaykina@gmail.com
Russian Federation, Tomsk, 634028
A. B. Shilova
Siberian State Medical University
Email: nadezhda.isaykina@gmail.com
Russian Federation, Tomsk, 634050