Synthesis and Antioxidant Activity of New Sulfur-Containing Derivatives of Isobornylphenols

Abstract

New derivatives of isobornylphenols containing a sulfur atom in the para-position in various functional groups have been synthesized. The evaluation of antiradical and antioxidant properties using various model systems has been carried out. The study has shown that compounds with a sulfhydryl group display the most antioxidant activity, which is determined by the presence of two reaction centers. It has been noticed that a number of terpenic substitutes in ortho-positions of the phenol molecule as well as the length of spacer between the aromatic nucleus and the functional group affect the activity. 2,6-Diisobornyl-4-sulfanylphenol (in low concentration exceeding the highly effective antioxidant 2,6-diisobornyl-4-methylphenol) shows considerable promise for investigating pharmacological activity.