Synthesis and neurotropic activity of the derivatives of fused triazolo[4,3-c]- and triazolo[1,5-c]pyrimidines
- Authors: Paronikyan E.G.1, Dashyan S.S.1, Paronikyan R.G.1, Dzhagatspanyan I.A.1, Nazaryan I.M.1, Akopyan A.G.1, Minasyan N.S.2
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Affiliations:
- Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center for Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific and Technological Center for Organic and Pharmaceutical Chemistry
- Issue: Vol 43, No 5 (2017)
- Pages: 595-603
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228696
- DOI: https://doi.org/10.1134/S1068162017040070
- ID: 228696
Cite item
Abstract
The methods for preparation of fused triazolo[4,3-c]- and triazolo[1,5-c]pyrimidines were developed. The Dimroth rearrangement of these systems was studied. Pharmacological investigation of the synthesized compounds was conducted in known tests, such as antagonism with subcutaneous administration of corazole and the open-field test. The rotating rod method was used to assess the neurotoxicity. Neurotropic properties were found in many derivatives of triazolopyrimidine. They, like diazepam, prevent the occurrence of clonic twitching and corazole-induced clonic convulsions in animals. All selected compounds as well as diazepam exhibit an anxiolytic effect.
About the authors
E. G. Paronikyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center for Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Armenia, Yerevan, 0014
Sh. Sh. Dashyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center for Organic and Pharmaceutical Chemistry
Author for correspondence.
Email: shdashyan@gmail.com
Armenia, Yerevan, 0014
R. G. Paronikyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center for Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Armenia, Yerevan, 0014
I. A. Dzhagatspanyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center for Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Armenia, Yerevan, 0014
I. M. Nazaryan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center for Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Armenia, Yerevan, 0014
A. G. Akopyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center for Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Armenia, Yerevan, 0014
N. S. Minasyan
Molecular Structure Research Center, Scientific and Technological Center for Organic and Pharmaceutical Chemistry
Email: shdashyan@gmail.com
Armenia, Yerevan, 0014