DNA sequence-specific ligands: XV. Synthesis and spectral characteristics of a new series of dimeric bisbenzimidazoles DB(1, 2, 6, 8, 9, 10, 12)
- Authors: Ivanov A.A.1, Salyanov V.I.2, Zhuze A.L.2
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Affiliations:
- Research Institute of Carcinogenesis, Blokhin Russian Oncological Research Center
- Engelhardt Institute of Molecular Biology
- Issue: Vol 42, No 2 (2016)
- Pages: 183-190
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/227873
- DOI: https://doi.org/10.1134/S1068162016020059
- ID: 227873
Cite item
Abstract
Seven fluorescent symmetric dimeric bisbenzimidazoles DB(n) capable of occupying up to one turn of the double-stranded B-form DNA have been designed and synthesized with the aim to develop DNAdependent enzyme inhibitors. The DB(n) compounds contain four 2,6-substituted benzimidazole fragments and differ by the length of the oligomethylene linker (n = 1, 2, 6, 8, 9, 10, 12) between the bisbenzimidazole blocks. The formation of DB(n)–double-stranded DNA complexes and the localization of the ligands in the DNA minor groove have been confirmed by a number of physicochemical methods.
About the authors
A. A. Ivanov
Research Institute of Carcinogenesis, Blokhin Russian Oncological Research Center
Email: zhuze@eimb.ru
Russian Federation, Kashirskoe sh. 24, Moscow, 115478
V. I. Salyanov
Engelhardt Institute of Molecular Biology
Email: zhuze@eimb.ru
Russian Federation, ul. Vavilova 32, Moscow, 119334
A. L. Zhuze
Engelhardt Institute of Molecular Biology
Author for correspondence.
Email: zhuze@eimb.ru
Russian Federation, ul. Vavilova 32, Moscow, 119334