Modification of biologically active amides and amines with fluorine-containing heterocycles

V. B. Sokolov; A. Yu. Aksinenko; T. V. Goreva; T. A. Epishina; S. O. Bachurin

doi:10.1007/s11172-019-2693-y

Modification of biologically active amides and amines with fluorine-containing heterocycles

作者: Sokolov V.¹, Aksinenko A.¹, Goreva T.¹, Epishina T.¹, Bachurin S.¹
隶属关系:
1. Institute of Physiologically Active Substances, Russian Academy of Sciences
期: 卷 68, 编号 12 (2019)
页面: 2241-2244
栏目: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/243554
DOI: https://doi.org/10.1007/s11172-019-2693-y
ID: 243554

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A synthetic approach to the modification of the drug “riluzole” with pharmacologically active fragments such as carbazole, tetrahydrocarbazole, phenothiazine, and aminothiophene, based on the copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of azide-containing pharmacophores with “riluzole” decorated with 5-trifluoromethylhydantoin, has been suggested.