Synthesis of 3,4-diaryl- and 4-acyl-3-arylpyrroles and study of their antimitotic activity
- 作者: Samet A.1, Sil’yanova E.1,2, Ushkarov V.1, Semenova M.3, Semenov V.1
-
隶属关系:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
- 期: 卷 67, 编号 5 (2018)
- 页面: 858-865
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242525
- DOI: https://doi.org/10.1007/s11172-018-2150-3
- ID: 242525
如何引用文章
详细
The Barton–Zard reaction of nitro substituted stilbenes and chalcones with ethyl isocyanoacetate afforded 3,4-diaryl- and 4-acyl-3-arylpyrroles, respectively. 3-Arylpyrrole-2,4- dicarboxylates and 4-arylisoxazoline N-oxides were side reaction products. Antimitotic activity of target 3,4-disubstituted pyrroles was studied on a sea urchin embryo model. Pyrroles unsubstituted at positions 2 and 5 were the most active. The activity increased with the number of methoxy groups in the Ar substituent.
作者简介
A. Samet
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: sametav@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991
E. Sil’yanova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences; D. I. Mendeleev University of Chemical Technology of Russia
Email: sametav@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991; 9 Miusskaya pl., Moscow, 125047
V. Ushkarov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: sametav@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991
M. Semenova
N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
Email: sametav@ioc.ac.ru
俄罗斯联邦, 26 ul. Vavilova, Moscow, 119334
V. Semenov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: sametav@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991