Synthesis of 3,4-diaryl- and 4-acyl-3-arylpyrroles and study of their antimitotic activity
- Авторлар: Samet A.1, Sil’yanova E.1,2, Ushkarov V.1, Semenova M.3, Semenov V.1
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Мекемелер:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
- Шығарылым: Том 67, № 5 (2018)
- Беттер: 858-865
- Бөлім: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242525
- DOI: https://doi.org/10.1007/s11172-018-2150-3
- ID: 242525
Дәйексөз келтіру
Аннотация
The Barton–Zard reaction of nitro substituted stilbenes and chalcones with ethyl isocyanoacetate afforded 3,4-diaryl- and 4-acyl-3-arylpyrroles, respectively. 3-Arylpyrrole-2,4- dicarboxylates and 4-arylisoxazoline N-oxides were side reaction products. Antimitotic activity of target 3,4-disubstituted pyrroles was studied on a sea urchin embryo model. Pyrroles unsubstituted at positions 2 and 5 were the most active. The activity increased with the number of methoxy groups in the Ar substituent.
Авторлар туралы
A. Samet
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: sametav@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991
E. Sil’yanova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences; D. I. Mendeleev University of Chemical Technology of Russia
Email: sametav@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991; 9 Miusskaya pl., Moscow, 125047
V. Ushkarov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: sametav@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991
M. Semenova
N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
Email: sametav@ioc.ac.ru
Ресей, 26 ul. Vavilova, Moscow, 119334
V. Semenov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: sametav@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991