Cerebral quantification of N-acetyl aspartate, aspartate, and glutamate levels in local structures of the human brain using J-editing of 1H magnetic resonance spectra in vivo
- 作者: Menshchikov P.1,2, Semenova N.1,2,3, Manzhurtsev A.2,3, Akhadov T.1, Varfolomeev S.3
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隶属关系:
- N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
- Scientific Research Institute of Emergency Children’s Surgery and Traumatology
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- 期: 卷 67, 编号 4 (2018)
- 页面: 655-662
- 栏目: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242427
- DOI: https://doi.org/10.1007/s11172-018-2119-2
- ID: 242427
如何引用文章
详细
A procedure was developed for the first time for simultaneous in vivo quantification of local aspartate and glutamate concentrations in the human brain using 1H magnetic resonance spectroscopy (1H MRS) and spectral J-editing. The MEGA-PRESS pulse sequence was modified to observe β-CH2 nonequivalent proton resonances of aspartate (δ 2.65 and 2.80) and glutamate (δ 2.04 and 2.12) overlapped by signals of other metabolites. The frequencies, frequency selective pulse durations, and optimal echo times were selected by simulation and experimentally (for phantoms and in the brain in vivo).
作者简介
P. Menshchikov
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences; Scientific Research Institute of Emergency Children’s Surgery and Traumatology
编辑信件的主要联系方式.
Email: peeterem@gmail.com
俄罗斯联邦, 4 ul. Kosygina, Moscow, Russian Federation, 119334; 22 ul. Bol’shaya Polyanka, Moscow, Russian Federation, 119180
N. Semenova
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences; Scientific Research Institute of Emergency Children’s Surgery and Traumatology; N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: peeterem@gmail.com
俄罗斯联邦, 4 ul. Kosygina, Moscow, Russian Federation, 119334; 22 ul. Bol’shaya Polyanka, Moscow, Russian Federation, 119180; 4 ul. Kosygina, Moscow, Russian Federation, 119334
A. Manzhurtsev
Scientific Research Institute of Emergency Children’s Surgery and Traumatology; N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: peeterem@gmail.com
俄罗斯联邦, 22 ul. Bol’shaya Polyanka, Moscow, Russian Federation, 119180; 4 ul. Kosygina, Moscow, Russian Federation, 119334
T. Akhadov
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: peeterem@gmail.com
俄罗斯联邦, 4 ul. Kosygina, Moscow, Russian Federation, 119334
S. Varfolomeev
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: peeterem@gmail.com
俄罗斯联邦, 4 ul. Kosygina, Moscow, Russian Federation, 119334