Мақаланы E-mail арқылы жіберу Nitro derivatives of 2,1,3-benzothiadiazole 1-oxides: synthesis, structural study, and NO release
- Авторлар: Konstantinova L.S.1, Knyazeva E.A.1, Gatilov Y.V.2, Zlotin S.G.1, Rakitin O.A.1
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Мекемелер:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
- Шығарылым: Том 67, № 1 (2018)
- Беттер: 95-101
- Бөлім: Article
- URL: https://journals.rcsi.science/1066-5285/article/view/241933
- DOI: https://doi.org/10.1007/s11172-018-2042-6
- ID: 241933
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Аннотация
A convenient one-pot synthesis of nitro derivatives of 2,1,3-benzothiadiazole 1-oxides by the reaction of o-nitroanilines with sulfur monochloride was developed. The structural features of 4-nitrobenzothiadiazole and its N-oxide were considered. High in vitro release of nitric oxide (69%) was found for a 6-nitro-2,1,3-benzothiadiazole sample by the Griess assay, which indicated good prospects for this class of compounds.
Авторлар туралы
L. Konstantinova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: orakitin@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991
E. Knyazeva
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: orakitin@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991
Yu. Gatilov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Email: orakitin@ioc.ac.ru
Ресей, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090
S. Zlotin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: orakitin@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991
O. Rakitin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: orakitin@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991
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