Conjugation of indole derivatives by copper-catalyzed alkyne-azide cycloaddition

V. B. Sokolov; А. Yu. Aksinenko; Т. А. Epishina; Т. V. Goreva; S. О. Bachurin

doi:10.1007/s11172-017-1931-4

Conjugation of indole derivatives by copper-catalyzed alkyne-azide cycloaddition

作者: Sokolov V.B.¹, Aksinenko А.Y.¹, Epishina Т.А.¹, Goreva Т.V.¹, Bachurin S.О.¹
隶属关系:
1. Institute of Physiologically Active Compounds, Russian Academy of Sciences
期: 卷 66, 编号 9 (2017)
页面: 1607-1610
栏目: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/241223
DOI: https://doi.org/10.1007/s11172-017-1931-4
ID: 241223

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详细

An efficient synthetic procedure to combine biologically active indole derivatives by the triazole-containing spacer in a molecule has been proposed. The procedure was based on a copper-catalyzed alkyne-azide cycloaddition of azide-containing carbazoles and N-propargyl-containing carbazoles, tetrahydrocarbazoles, and tetrahydro-γ-carbolines.