Synthesis and membrane-protective activity of 4-aminomethyl derivatives of 2,6-diisobornylphenol
- 作者: Buravlev E.V.1, Chukicheva I.Y.1, Shevchenko O.G.2, Suponitskii K.Y.3, Kutchin A.V.1
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隶属关系:
- Institute of Chemistry, Komi Scienific Centre, Ural Branch of the Russian Academy of Sciences
- Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- 期: 卷 66, 编号 1 (2017)
- 页面: 91-98
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239833
- DOI: https://doi.org/10.1007/s11172-017-1705-z
- ID: 239833
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详细
A series of 4-aminomethyl derivatives of 2,6-diisobornylphenol containing tertiary and secondary amino groups were synthesized. Their toxicity and the membrane-protective and antioxidant activity were assessed using red blood cells of laboratory mice as the test object. These compounds were shown to exhibit high membrane-protective and antioxidant activity, which substantially depends on the structure of the substituent and the concentration of the substance.
作者简介
E. Buravlev
Institute of Chemistry, Komi Scienific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167000
I. Chukicheva
Institute of Chemistry, Komi Scienific Centre, Ural Branch of the Russian Academy of Sciences
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Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167000
O. Shevchenko
Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 28 ul. Kommunisticheskaya, Syktyvkar, 167982
K. Suponitskii
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991
A. Kutchin
Institute of Chemistry, Komi Scienific Centre, Ural Branch of the Russian Academy of Sciences
Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167000
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