Synthesis and membrane-protective activity of 4-aminomethyl derivatives of 2,6-diisobornylphenol


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A series of 4-aminomethyl derivatives of 2,6-diisobornylphenol containing tertiary and secondary amino groups were synthesized. Their toxicity and the membrane-protective and antioxidant activity were assessed using red blood cells of laboratory mice as the test object. These compounds were shown to exhibit high membrane-protective and antioxidant activity, which substantially depends on the structure of the substituent and the concentration of the substance.

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E. Buravlev

Institute of Chemistry, Komi Scienific Centre, Ural Branch of the Russian Academy of Sciences

Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167000

I. Chukicheva

Institute of Chemistry, Komi Scienific Centre, Ural Branch of the Russian Academy of Sciences

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Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167000

O. Shevchenko

Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences

Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 28 ul. Kommunisticheskaya, Syktyvkar, 167982

K. Suponitskii

A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991

A. Kutchin

Institute of Chemistry, Komi Scienific Centre, Ural Branch of the Russian Academy of Sciences

Email: chukicheva-iy@chemi.komisc.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167000

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