Synthesis and search for compounds with hemostatic activity in the series of 4-(het)aryl-4-oxobut-2-enoic acid derivatives
- Авторы: Pulina N.1, Kozhukhar V.1, Kuznetsov A.1, Rubtsov A.2, Starkova A.1
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Учреждения:
- Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
- Perm State National Research University
- Выпуск: Том 66, № 8 (2017)
- Страницы: 1497-1502
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/241135
- DOI: https://doi.org/10.1007/s11172-017-1914-5
- ID: 241135
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Аннотация
New 4-aryl-2-(4-arylamino)-1-(piperazin-1-yl)but-2-ene-1,4-diones and 2-{[2-(3-R-adamantan-1-yl)-2-oxoethylidene]hydrazinyl}-4-(het)aryl-4-oxobut-2-enoic acids were synthesized and used to obtain water-soluble compounds. Their influence on the blood coagulation system was studied, which revealed compounds with a high hemostatic activity and a low acute toxicity. A relationship between structure and pharmacological effect of the synthesized compounds was established.
Об авторах
N. Pulina
Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
Email: slavaperm@inbox.ru
Россия, 2 ul. Polevaya, Perm, 614990
V. Kozhukhar
Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
Автор, ответственный за переписку.
Email: slavaperm@inbox.ru
Россия, 2 ul. Polevaya, Perm, 614990
A. Kuznetsov
Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
Email: slavaperm@inbox.ru
Россия, 2 ul. Polevaya, Perm, 614990
A. Rubtsov
Perm State National Research University
Email: slavaperm@inbox.ru
Россия, 15 ul. Bukireva, Perm, 614990
A. Starkova
Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
Email: slavaperm@inbox.ru
Россия, 2 ul. Polevaya, Perm, 614990