Email this article Synthesis and search for compounds with hemostatic activity in the series of 4-(het)aryl-4-oxobut-2-enoic acid derivatives
- Authors: Pulina N.A.1, Kozhukhar V.Y.1, Kuznetsov A.S.1, Rubtsov A.E.2, Starkova A.V.1
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Affiliations:
- Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
- Perm State National Research University
- Issue: Vol 66, No 8 (2017)
- Pages: 1497-1502
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/241135
- DOI: https://doi.org/10.1007/s11172-017-1914-5
- ID: 241135
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Abstract
New 4-aryl-2-(4-arylamino)-1-(piperazin-1-yl)but-2-ene-1,4-diones and 2-{[2-(3-R-adamantan-1-yl)-2-oxoethylidene]hydrazinyl}-4-(het)aryl-4-oxobut-2-enoic acids were synthesized and used to obtain water-soluble compounds. Their influence on the blood coagulation system was studied, which revealed compounds with a high hemostatic activity and a low acute toxicity. A relationship between structure and pharmacological effect of the synthesized compounds was established.
About the authors
N. A. Pulina
Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
Email: slavaperm@inbox.ru
Russian Federation, 2 ul. Polevaya, Perm, 614990
V. Yu. Kozhukhar
Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: slavaperm@inbox.ru
Russian Federation, 2 ul. Polevaya, Perm, 614990
A. S. Kuznetsov
Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
Email: slavaperm@inbox.ru
Russian Federation, 2 ul. Polevaya, Perm, 614990
A. E. Rubtsov
Perm State National Research University
Email: slavaperm@inbox.ru
Russian Federation, 15 ul. Bukireva, Perm, 614990
A. V. Starkova
Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation
Email: slavaperm@inbox.ru
Russian Federation, 2 ul. Polevaya, Perm, 614990
