Potential synthetic adaptogens 1. Synthesis and studies of new  N -[(adamantan-1-yl)methyl]aniline derivatives based on adamantane-1-carbaldehyde

S. N. Voloboev; A. V. Andreev; A. S. Mkrtchyan; M. B. Navrotskii; I. A. Novakov; B. S. Orlinson; V. V. Son

doi:10.1007/s11172-016-1458-0

Potential synthetic adaptogens 1. Synthesis and studies of new N-[(adamantan-1-yl)methyl]aniline derivatives based on adamantane-1-carbaldehyde

Autores: Voloboev S.N.¹, Andreev A.V.², Mkrtchyan A.S.², Navrotskii M.B.², Novakov I.A.², Orlinson B.S.², Son V.V.³
Afiliações:
1. OOO “LUKOIL-Volgogradneftepererabotka”
2. Volgograd State Technical University
3. Volgograd State Agricultural University
Edição: Volume 65, Nº 5 (2016)
Páginas: 1336-1340
Seção: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/238241
DOI: https://doi.org/10.1007/s11172-016-1458-0
ID: 238241

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Resumo

A number of new N-[(adamantan-1-yl)methyl]aniline derivatives, which can be considered as conformationally labile analogues of synthetic adaptogen Bromantan, were obtained by the reductive amination reaction of adamantane-1-carbaldehyde with aromatic amines. The influence of the reaction conditions of reductive amination on the yield and composition of its products was studied.