Synthesis and biological activity of fluorine-containing amino derivatives based on 4-caranethiol

D. V. Sudarikov; Yu. V. Krymskaya; N. O. Il’chenko; P. A. Slepukhin; S. A. Rubtsova; A. V. Kutchin

doi:10.1007/s11172-018-2130-7

Synthesis and biological activity of fluorine-containing amino derivatives based on 4-caranethiol

Autores: Sudarikov D.V.¹, Krymskaya Y.V.¹, Il’chenko N.O.¹, Slepukhin P.A.²^,3, Rubtsova S.A.¹, Kutchin A.V.¹
Afiliações:
1. Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
2. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
3. Ural Federal University named after the First President of Russia B. N. Yeltsin
Edição: Volume 67, Nº 4 (2018)
Páginas: 731-742
Seção: Full Article
URL: https://journals.rcsi.science/1066-5285/article/view/242455
DOI: https://doi.org/10.1007/s11172-018-2130-7
ID: 242455

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Fluorine-containing N-substituted sulfinamides were synthesized via 4-caranethiol-based sulfenimines and sulfinimines. Stereochemical features of oxidation of sulfenimines and addition of fluorine-containing reagents to sulfinimines were discussed. Antimicrobial activities of the obtained compounds were screened.