Modification of biologically active amides and amines with fluoro-containing heterocycles 13.* Carbazoles and tetrahydrocarbazoles modified with 2-substituted (imidazo[1,2-a]pyridine-3-yl)propionamidic fragments

Resumo

An approach to modify biologically active carbazoles and tetrahydrocarbazoles with 2-trifluoromethyl and 2-methoxycarbonyl(imidazo[1,2-a]pyridin-3-yl)propionylamidic fragments by interaction of N-methyl-N-[2-trifluoromethylimidazo[1,2-a]pyridin-3-yl]prop-2-ene amides and N-methyl-N-[2-methoxycarbonylimidazo[1,2-a]pyridin-3-yl]prop-2-ene amides with carbazoles and tetrahydrocarbazoles in the presence of catalytic amounts of cesium fluoride was proposed. Effect of compounds synthesized on neuronal NMDA receptors using radioligand binding method was studied.