Synthesis of complexes of N-vinylpyrrolidone–vinylamine or N-vinylpyrrolidone–allylamine containing macrocyclic polyligand 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA) with gallium-68 isotope and estimation of their in vivo distribution
- Autores: Gorshkov N.1, Shatik S.2, Tokarev A.2, Gavrilova I.1, Nazarova O.1, Murko A.1, Krasikov V.1, Panarin E.1,3
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Afiliações:
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of the Russian Federation
- St. Petersburg State Polytechnical University
- Edição: Volume 66, Nº 1 (2017)
- Páginas: 156-163
- Seção: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239924
- DOI: https://doi.org/10.1007/s11172-017-1714-y
- ID: 239924
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Resumo
A method for radiolabeling the water-soluble N-vinylpyrrolidone copolymers with N-vinyl- and N-allylamine containing bifunctional chelation unit 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetate by the radioactive isotope gallium-68 (68Ga) was developed. Radiotracers were obtained in the yield about 65%. A method of liquid chromatography for the micropreparative isolation of the metal-polymeric complexes with a radiochemical purity of ~98% was developed. The data on the stability of the complexes in blood serum and the results on the biodistribution of the synthesized complexes in organs and tissues of laboratory animals (rats) with transplantable tumor are presented.
Sobre autores
N. Gorshkov
Institute of Macromolecular Compounds, Russian Academy of Sciences
Autor responsável pela correspondência
Email: ngorshkov@mail.ru
Rússia, 31 Bol´shoi prosp., St. Petersburg, 199004
S. Shatik
Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of the Russian Federation
Email: ngorshkov@mail.ru
Rússia, 70 ul. Leningradskaya, p. Pesochnyi, St. Petersburg, 197758
A. Tokarev
Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of the Russian Federation
Email: ngorshkov@mail.ru
Rússia, 70 ul. Leningradskaya, p. Pesochnyi, St. Petersburg, 197758
I. Gavrilova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: ngorshkov@mail.ru
Rússia, 31 Bol´shoi prosp., St. Petersburg, 199004
O. Nazarova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: ngorshkov@mail.ru
Rússia, 31 Bol´shoi prosp., St. Petersburg, 199004
A. Murko
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: ngorshkov@mail.ru
Rússia, 31 Bol´shoi prosp., St. Petersburg, 199004
V. Krasikov
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: ngorshkov@mail.ru
Rússia, 31 Bol´shoi prosp., St. Petersburg, 199004
E. Panarin
Institute of Macromolecular Compounds, Russian Academy of Sciences; St. Petersburg State Polytechnical University
Email: ngorshkov@mail.ru
Rússia, 31 Bol´shoi prosp., St. Petersburg, 199004; 29 ul. Politekhnicheskaya, St. Petersburg, 195251