Synthesis of complexes of N-vinylpyrrolidone–vinylamine or N-vinylpyrrolidone–allylamine containing macrocyclic polyligand 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA) with gallium-68 isotope and estimation of their in vivo distribution
- Authors: Gorshkov N.I.1, Shatik S.V.2, Tokarev A.V.2, Gavrilova I.I.1, Nazarova O.V.1, Murko A.Y.1, Krasikov V.D.1, Panarin E.F.1,3
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Affiliations:
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of the Russian Federation
- St. Petersburg State Polytechnical University
- Issue: Vol 66, No 1 (2017)
- Pages: 156-163
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239924
- DOI: https://doi.org/10.1007/s11172-017-1714-y
- ID: 239924
Cite item
Abstract
A method for radiolabeling the water-soluble N-vinylpyrrolidone copolymers with N-vinyl- and N-allylamine containing bifunctional chelation unit 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetate by the radioactive isotope gallium-68 (68Ga) was developed. Radiotracers were obtained in the yield about 65%. A method of liquid chromatography for the micropreparative isolation of the metal-polymeric complexes with a radiochemical purity of ~98% was developed. The data on the stability of the complexes in blood serum and the results on the biodistribution of the synthesized complexes in organs and tissues of laboratory animals (rats) with transplantable tumor are presented.
About the authors
N. I. Gorshkov
Institute of Macromolecular Compounds, Russian Academy of Sciences
Author for correspondence.
Email: ngorshkov@mail.ru
Russian Federation, 31 Bol´shoi prosp., St. Petersburg, 199004
S. V. Shatik
Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of the Russian Federation
Email: ngorshkov@mail.ru
Russian Federation, 70 ul. Leningradskaya, p. Pesochnyi, St. Petersburg, 197758
A. V. Tokarev
Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of the Russian Federation
Email: ngorshkov@mail.ru
Russian Federation, 70 ul. Leningradskaya, p. Pesochnyi, St. Petersburg, 197758
I. I. Gavrilova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: ngorshkov@mail.ru
Russian Federation, 31 Bol´shoi prosp., St. Petersburg, 199004
O. V. Nazarova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: ngorshkov@mail.ru
Russian Federation, 31 Bol´shoi prosp., St. Petersburg, 199004
A. Yu. Murko
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: ngorshkov@mail.ru
Russian Federation, 31 Bol´shoi prosp., St. Petersburg, 199004
V. D. Krasikov
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: ngorshkov@mail.ru
Russian Federation, 31 Bol´shoi prosp., St. Petersburg, 199004
E. F. Panarin
Institute of Macromolecular Compounds, Russian Academy of Sciences; St. Petersburg State Polytechnical University
Email: ngorshkov@mail.ru
Russian Federation, 31 Bol´shoi prosp., St. Petersburg, 199004; 29 ul. Politekhnicheskaya, St. Petersburg, 195251