The complex of zinc with N-(5,6-dihydro-4H-1,3-thiazine-2-yl)benzamide
- Авторлар: Trofimova T.1,2, Orlova M.1,2, Severin A.1, Shalamova E.1, Proshin A.3, Orlov A.1
-
Мекемелер:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- D. Rogachev National Research Clinical Center of Pediatric Hematology, Oncology, and Immunology
- Institute of Physiological Active Compounds of Russian Academy of Sciences
- Шығарылым: Том 67, № 4 (2018)
- Беттер: 768-773
- Бөлім: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242472
- DOI: https://doi.org/10.1007/s11172-018-2135-2
- ID: 242472
Дәйексөз келтіру
Аннотация
A complex of zinc with N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide (L) ligand, LZnCl2, was synthesized for subsequent medical trials. The molar extinction coefficients were determined for LHBr solutions in water and physiological saline, and for LZnCl2 ethanol solution. The ligand stability in various solvents was evaluated and the value of its protonation constant was found for the physiological saline solution, logK = 5.3±0.2. The impossibility of determination of the complex stability constant by the potentiometric titration method was demonstrated. The complex exhibited an insufficient stability in aqueous and physiological saline solutions, but was stable as the solution in alcohol. There was no sorption observed upon the treatment of ligand with hydroxyapatite nanoparticles, which could be a potential carrier for the therapeutic form of LZnCl2, providing additional degrees of freedom for the interaction of ligand with cell membranes and a prolonged action of zinc ions.
Авторлар туралы
T. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; D. Rogachev National Research Clinical Center of Pediatric Hematology, Oncology, and Immunology
Email: orlova.radiochem@mail.ru
Ресей, Bld. 3, 1 Leninskie Gory, Moscow, Russian Federation, 119991; 1 ul. Samory Mashela, Moscow, Russian Federation, 117997
M. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; D. Rogachev National Research Clinical Center of Pediatric Hematology, Oncology, and Immunology
Хат алмасуға жауапты Автор.
Email: orlova.radiochem@mail.ru
Ресей, Bld. 3, 1 Leninskie Gory, Moscow, Russian Federation, 119991; 1 ul. Samory Mashela, Moscow, Russian Federation, 117997
A. Severin
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Ресей, Bld. 3, 1 Leninskie Gory, Moscow, Russian Federation, 119991
E. Shalamova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Ресей, Bld. 3, 1 Leninskie Gory, Moscow, Russian Federation, 119991
A. Proshin
Institute of Physiological Active Compounds of Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
Ресей, 1 Severnyi proezd, Chernogolovka, Moscow Region, Russian Federation, 142432
A. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Ресей, Bld. 3, 1 Leninskie Gory, Moscow, Russian Federation, 119991