Immobilized phthalocyanines of magnesium, aluminum, and zinc in photodynamic treatment of mesenchymal stromal cells
- Авторлар: Andreeva E.1, Buravkova L.1,2, Melnikov M.3, Udartseva O.1, Lobanov A.4,5
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Мекемелер:
- Institute of Biomedical Problems, Russian Academy of Sciences
- Department of Fundamental Medicine, M. V. Lomonosov Moscow State University
- Department of Chemistry, M. V. Lomonosov Moscow State University
- N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
- G. V. Plekhanov Russian University of Economics
- Шығарылым: Том 65, № 1 (2016)
- Беттер: 277-281
- Бөлім: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/237042
- DOI: https://doi.org/10.1007/s11172-016-1297-z
- ID: 237042
Дәйексөз келтіру
Аннотация
Phthalocyanines of magnesium, aluminum, and zinc immobilized on nano-sized silica and poly-N-vinylpyrrolidone in aqueous solutions were synthesized. Photochemical activity of the immobilized metal complexes was assessed by generation of singlet oxygen. Nontoxic concentrations of the new photosensitizers were determined in vitro. A comparative analysis of the efficiency of photodynamic therapy (PDT) was performed for immobilized phthalocyanines using mesenchymal stromal cells as a cell model. Aluminum phthalocyanine immobilized on nano-sized silica displayed the highest cell tropism. Irradiation of phthalocyanine-loaded cells resulted in generation of active singlet oxygen and subsequent apoptotic cell death. The use of immobilized phthalocyanines allowed decreasing the effective concentration (dose) of photosensitizer and enhancing the PDT cytotoxicity.
Негізгі сөздер
Авторлар туралы
E. Andreeva
Institute of Biomedical Problems, Russian Academy of Sciences
Email: avlobanov@mail.ru
Ресей, 76A Khoroshevskoe shosse, Moscow, 123007
L. Buravkova
Institute of Biomedical Problems, Russian Academy of Sciences; Department of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: avlobanov@mail.ru
Ресей, 76A Khoroshevskoe shosse, Moscow, 123007; 31/5 Lomonosovskiy prosp., Moscow, 119192
M. Melnikov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: avlobanov@mail.ru
Ресей, 1/3 Leninskie Gory, Moscow, 119991
O. Udartseva
Institute of Biomedical Problems, Russian Academy of Sciences
Email: avlobanov@mail.ru
Ресей, 76A Khoroshevskoe shosse, Moscow, 123007
A. Lobanov
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences; G. V. Plekhanov Russian University of Economics
Хат алмасуға жауапты Автор.
Email: avlobanov@mail.ru
Ресей, 4 ul. Kosygina, Moscow, 119991; 36 Stremyanny per., Moscow, 117997