Modification of biologically active amides and amines with fluorine-containing heterocycles
- Authors: Sokolov V.B.1, Aksinenko A.Y.1, Goreva T.V.1, Epishina T.A.1, Bachurin S.O.1
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Affiliations:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Issue: Vol 68, No 12 (2019)
- Pages: 2241-2244
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243554
- DOI: https://doi.org/10.1007/s11172-019-2693-y
- ID: 243554
Cite item
Abstract
A synthetic approach to the modification of the drug “riluzole” with pharmacologically active fragments such as carbazole, tetrahydrocarbazole, phenothiazine, and aminothiophene, based on the copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of azide-containing pharmacophores with “riluzole” decorated with 5-trifluoromethylhydantoin, has been suggested.
About the authors
V. B. Sokolov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Sevemyiproezd, Chernogolovka, Moscow Region, 142432
A. Yu. Aksinenko
Institute of Physiologically Active Substances, Russian Academy of Sciences
Author for correspondence.
Email: alaks@ipac.ac.ru
Russian Federation, 1 Sevemyiproezd, Chernogolovka, Moscow Region, 142432
T. V. Goreva
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Sevemyiproezd, Chernogolovka, Moscow Region, 142432
T. A. Epishina
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Sevemyiproezd, Chernogolovka, Moscow Region, 142432
S. O. Bachurin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Sevemyiproezd, Chernogolovka, Moscow Region, 142432