Multifunctional polymer dispersions for biomedical assays obtained by heterophase radical polymerization
- Authors: Generalova A.N.1,2, Asharchuk I.M.2, Zubov V.P.1
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Affiliations:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences
- Issue: Vol 67, No 10 (2018)
- Pages: 1759-1780
- Section: Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243070
- DOI: https://doi.org/10.1007/s11172-018-2289-y
- ID: 243070
Cite item
Abstract
Methods for the preparation of multifunctional dispersions of polymer particles (DPP) in the course of free radical heterophase polymerization, which provides careful control of both macromolecular and colloidal properties, are considered. Approaches that, according to the polymerization technique, make it possible to control the particle diameter and shape, particle size distribution, colloidal stability, morphology, surface chemistry and functionality, as well as the formation of organo-inorganic hybrid particles, are demonstrated. The possibilities of DPP application in homogeneous and heterogeneous assays and cell labelling are reviewed. The use of DPP leads to decrease the reaction scales and costs and to increase the speed, sensitivity, selectivity, and reproducibility of assays.
About the authors
A. N. Generalova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences
Author for correspondence.
Email: a-generalova@yandex.ru
Russian Federation, 16/10 ul. Miklukho-Maklaya, Moscow, 117997; 59 Leninsky prosp., Moscow, 119333
I. M. Asharchuk
Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences
Email: a-generalova@yandex.ru
Russian Federation, 59 Leninsky prosp., Moscow, 119333
V. P. Zubov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: a-generalova@yandex.ru
Russian Federation, 16/10 ul. Miklukho-Maklaya, Moscow, 117997