Email this article Antistress properties of sodium 1-N-acetylamino-1-carboxy-2-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
- Authors: Zhigacheva I.V.1, Rasulov M.M.2
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Affiliations:
- M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- State Research Institute for Chemistry and Technology of Organoelement Compounds
- Issue: Vol 67, No 4 (2018)
- Pages: 721-725
- Section: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242447
- DOI: https://doi.org/10.1007/s11172-018-2128-1
- ID: 242447
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Abstract
The effect of a spatially-hindered phenol, namely sodium 1-N-acetylamino-1-carboxy-2-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, on the functionality of mitochondria of rat liver was studied. Stress impact caused a 3 to 4-fold increase in the fluorescence intensity of the products of lipid peroxidation (LPO) in the membranes of these organelles. The preparation reduced the intensity of LPO to the control level, which was conductive to maintaining high functional activity of the mitochondria. Prevention of mitochondrial dysfunction was probably associated with an increase in the resistance of animals to stress factors.
About the authors
I. V. Zhigacheva
M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: zhigacheva@mail.ru
Russian Federation, 4 ul. Kosygina, Moscow, Russian Federation, 119334
M. M. Rasulov
State Research Institute for Chemistry and Technology of Organoelement Compounds
Email: zhigacheva@mail.ru
Russian Federation, 38 sh. Entuziastov, Moscow, Russian Federation, 105118
