Email this article Synthesis of oxalic acid derivatives and their antitumor activity in experiments in vivo
- Authors: Fedorov B.S.1, Goncharova S.A.1, Rajevskaya T.A.1, Eremeev A.B.1, Utenyshev A.N.1, Fadeev M.A.1, Bogdanov G.N.1, Konovalova N.P.1, Aldoshin S.M.1
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Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Issue: Vol 67, No 4 (2018)
- Pages: 694-699
- Section: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242437
- DOI: https://doi.org/10.1007/s11172-018-2124-5
- ID: 242437
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Abstract
A series of amino acid derivatives of oxalic acid were obtained. In combination therapy with conventional cytostatics used in lower doses, the new compounds substantially increase the efficacy of the drugs in the treatment of experimental P388 murine leukemia and some its drug-resistant strains.
About the authors
B. S. Fedorov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: tara@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, Russian Federation, 142432
S. A. Goncharova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: tara@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, Russian Federation, 142432
T. A. Rajevskaya
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: tara@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, Russian Federation, 142432
A. B. Eremeev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: tara@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, Russian Federation, 142432
A. N. Utenyshev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: tara@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, Russian Federation, 142432
M. A. Fadeev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: tara@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, Russian Federation, 142432
G. N. Bogdanov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: tara@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, Russian Federation, 142432
N. P. Konovalova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: tara@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, Russian Federation, 142432
S. M. Aldoshin
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: tara@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, Russian Federation, 142432
