Ferrocenecarboxylic acid and microwave-assisted synthesis of ferrocenoyl hydrazones
- Authors: Kulikov V.N.1,2, Nikulin R.S.1,2, Arkhipov D.E.1, Rodionov A.N.1, Babusenko E.S.2, Kovalenko L.V.2, Belousov Y.A.1
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Affiliations:
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- D. Mendeleev University of Chemical Technology of Russia
- Issue: Vol 66, No 3 (2017)
- Pages: 537-544
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240274
- DOI: https://doi.org/10.1007/s11172-017-1768-x
- ID: 240274
Cite item
Abstract
A protocol to access ferrocenecarboxylic acid via carboxylation of ferrocene with carbon dioxide in the presence of aluminum chloride was elaborated. An efficient microwave-assisted synthesis of ferrocenoyl hydrazones by condensation of ferrocene carbohydrazide with carbonyl compounds was developed. Structures of the synthesized compounds were examined by NMR spectroscopy and mass spectrometry. Structures of N´-(4-chlorobenzylidene)ferrocenecarbohydrazide, N´-(4-methoxybenzylidene)ferrocenecarbohydrazide, and N´-(2-hydroxybenzylidene)ferrocenecarbohydrazide were determined by X-ray diffraction analysis. Synthesized compounds were found to have no toxicity against P. aeruginosa, E. coli, S. aureus, B. subtilis, M. rubrum, and C. albicans.
About the authors
V. N. Kulikov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences; D. Mendeleev University of Chemical Technology of Russia
Author for correspondence.
Email: kulikov_v_n@mail.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991; 9 Miusskaya pl., Moscow, 125047
R. S. Nikulin
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences; D. Mendeleev University of Chemical Technology of Russia
Email: belur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991; 9 Miusskaya pl., Moscow, 125047
D. E. Arkhipov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: belur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
A. N. Rodionov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: belur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
E. S. Babusenko
D. Mendeleev University of Chemical Technology of Russia
Email: belur@ineos.ac.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047
L. V. Kovalenko
D. Mendeleev University of Chemical Technology of Russia
Email: belur@ineos.ac.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047
Yu. A. Belousov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Author for correspondence.
Email: belur@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991