Email this article Pentapeptide analogs of somatostatin containing a thiazolidine fragment: synthesis and cytotoxic activity
- Authors: Balaev A.N.1, Osipov V.N.1,2, Okhmanovich K.A.1, Ruchko E.A.1, Baryshnikova M.A.3, Khachatryan D.S.2
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Affiliations:
- Pharm-Sintez
- State Scientific-Research Institute of Chemical Reagents and High Purity Substances (IREA)
- N. N. Blokhin Russian Cancer Scientific Center, Ministry of Healthcare of Russian Federation
- Issue: Vol 65, No 12 (2016)
- Pages: 2948-2951
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239692
- DOI: https://doi.org/10.1007/s11172-016-1683-6
- ID: 239692
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Abstract
Pentapeptide analogs of somatostatin containing an (R)-1,3-thiazolidine fragment (Thz) of the general formula X—Thz—Phe—D-Trp—Lys(Y)—Thr—Z were synthesized for the first time. The synthesized compounds were tested for cytotoxic activity against three cancer cell lines (MCF-7, PC3, and HCT-116) and against human embryo fibroblasts.
About the authors
A. N. Balaev
Pharm-Sintez
Email: derenik-s@yandex.ru
Russian Federation, 29, Build. 134, ul. Vereiskaya, Moscow, 121357
V. N. Osipov
Pharm-Sintez; State Scientific-Research Institute of Chemical Reagents and High Purity Substances (IREA)
Email: derenik-s@yandex.ru
Russian Federation, 29, Build. 134, ul. Vereiskaya, Moscow, 121357; 3 ul. Bogorodsky val, Moscow, 107076
K. A. Okhmanovich
Pharm-Sintez
Email: derenik-s@yandex.ru
Russian Federation, 29, Build. 134, ul. Vereiskaya, Moscow, 121357
E. A. Ruchko
Pharm-Sintez
Email: derenik-s@yandex.ru
Russian Federation, 29, Build. 134, ul. Vereiskaya, Moscow, 121357
M. A. Baryshnikova
N. N. Blokhin Russian Cancer Scientific Center, Ministry of Healthcare of Russian Federation
Email: derenik-s@yandex.ru
Russian Federation, 23 Kashirskoe shosse, Moscow, 115478
D. S. Khachatryan
State Scientific-Research Institute of Chemical Reagents and High Purity Substances (IREA)
Author for correspondence.
Email: derenik-s@yandex.ru
Russian Federation, 3 ul. Bogorodsky val, Moscow, 107076
