电邮这篇文章 New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids
- 作者: Yamansarov E.Y.1, Skvortsov D.A.1, Lopukhov A.V.1, Kovalev S.V.1, Evteev S.A.1, Petrov R.A.1, Klyachko N.L.1,2, Zyk N.V.1, Beloglazkina E.K.1, Ivanenkov Y.A.3,4, Majouga A.G.1,5,6
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隶属关系:
- Lomonosov Moscow State University
- Skolkovo Institute of Science and Technology
- Institute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences
- Moscow Institute of Physics and Technology (State University)
- National University of Science and Technology MISiS
- Dmitry Mendeleev University of Chemical Technology of Russia
- 期: 卷 68, 编号 12 (2019)
- 页面: 2331-2338
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243567
- DOI: https://doi.org/10.1007/s11172-019-2707-9
- ID: 243567
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详细
New ligands for targeted delivery to the liver based on glycoconjugated natural triterpenoids are proposed. Simple chemical transformations of starting lupane triterpenes led to betulin or betulinic acid conjugates with N-acetyl-d-galactosamine linked through an isopropenyl fragment of the terpene skeleton. The obtained compounds were non-toxic in vitro to a series of cancer cell lines and normal cells. Molecular docking in silico and surface plasmon resonance spectroscopy revealed a high specificity of the synthesized glycotriterpenoids to the asialogly-coprotein receptor of hepatocytes.
作者简介
E. Yamansarov
Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991
D. Skvortsov
Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991
A. Lopukhov
Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991
S. Kovalev
Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991
S. Evteev
Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991
R. Petrov
Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991
N. Klyachko
Lomonosov Moscow State University; Skolkovo Institute of Science and Technology
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991; 100 ul. Novaya, Skolkovo, 143025
N. Zyk
Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991
E. Beloglazkina
Lomonosov Moscow State University
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991
Ya. Ivanenkov
Institute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences; Moscow Institute of Physics and Technology (State University)
Email: jamansar@gmail.com
俄罗斯联邦, 71 prosp. Oktyabrya, Ufa, 450054; 9 Instituskiiper., Dolgoprudnyi, Moscow region, 141701
A. Majouga
Lomonosov Moscow State University; National University of Science and Technology MISiS; Dmitry Mendeleev University of Chemical Technology of Russia
Email: jamansar@gmail.com
俄罗斯联邦, 1 Leninskie Gory, Moscow, 119991; 4 Leninskiiprosp., Moscow, 119049; 1 Build., 9 Miusskaya pl., Moscow, 125047
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