Email this article Three-component green synthesis of 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, a promising antituberculosis drug
- Authors: Titova Y.A.1, Fedorova O.V.1, Rusinov G.L.1,2, Charushin V.N.1,2
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Affiliations:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B. N. Yeltsin
- Issue: Vol 68, No 12 (2019)
- Pages: 2271-2274
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243558
- DOI: https://doi.org/10.1007/s11172-019-2698-6
- ID: 243558
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Abstract
A new simple, technological, and environmentally friendly method for the catalyst-free synthesis in water of a promising antituberculosis drug, 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, was developed. The amount of the solvent in the reaction mixture has a decisive effect on the yield and purity of the target product.
About the authors
Yu. A. Titova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: titova@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990
O. V. Fedorova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: titova@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990
G. L. Rusinov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: titova@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990; 19 ul. Mira, Yekaterinburg, 620002
V. N. Charushin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: titova@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoi, Yekaterinburg, 620990; 19 ul. Mira, Yekaterinburg, 620002
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