Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo
- Авторы: Faustova M.R.1,2, Nikolskaya E.D.1,3, Mollaev M.D.2, Sokol M.B.1, Zabolotsky A.I.1, Zhunina O.A.1,3, Fomicheva M.V.1, Schvets V.I.2, Lobanov A.V.3, Yabbarov N.G.1,3
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							Учреждения: 
							- Russian Research Center for Molecular Diagnostics and Therapy
- MIREA — Russian Technological University, Institute of Fine Chemical Technologies
- N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
 
- Выпуск: Том 68, № 12 (2019)
- Страницы: 2216-2224
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243551
- DOI: https://doi.org/10.1007/s11172-019-2690-1
- ID: 243551
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Аннотация
Reactive oxygen species are generated by the redox reaction involving metalloporphyrin and ascorbic acid (AA) and lead to oxidative stress followed by cancer cell death. Polymer particles based on the copolymer of lactic and glycolic acid (PLGA) containing FeIIICl-tetraphenylporphyrin (FeClTPP) were prepared and characterized. These particles in combination with AA exhibit cytotoxic activity against the K562 (human chronic myelogenous leukemia) and MCF7 (human breast adenocarcinoma) cell lines. Results in vitro indicated significant antitumor efficiency on mice inoculated with P388 leukemic cells and treated with FeClTPP/AA. The cytotoxic activity of the combined system is achieved due to the formation of reactive oxygen species. The application of this system to the study of anticancer efficiency in vivo on the model of mice that were hypodermically inoculated with P388 lymphocytic leukemia revealed a significant inhibition of tumor growth. The use of FeClTPP in combination with AA seems to be promising in cancer treatment.
Об авторах
M. Faustova
Russian Research Center for Molecular Diagnostics and Therapy; MIREA — Russian Technological University, Institute of Fine Chemical Technologies
							Автор, ответственный за переписку.
							Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							8 Simferopol’sky bulv., Moscow, 117638; 78 prosp. Vernadskogo, Moscow, 119454						
E. Nikolskaya
Russian Research Center for Molecular Diagnostics and Therapy; N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
														Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							8 Simferopol’sky bulv., Moscow, 117638; 4 ul. Kosygina, Moscow, 119991						
M. Mollaev
MIREA — Russian Technological University, Institute of Fine Chemical Technologies
														Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							78 prosp. Vernadskogo, Moscow, 119454						
M. Sokol
Russian Research Center for Molecular Diagnostics and Therapy
														Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							8 Simferopol’sky bulv., Moscow, 117638						
A. Zabolotsky
Russian Research Center for Molecular Diagnostics and Therapy
														Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							8 Simferopol’sky bulv., Moscow, 117638						
O. Zhunina
Russian Research Center for Molecular Diagnostics and Therapy; N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
														Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							8 Simferopol’sky bulv., Moscow, 117638; 4 ul. Kosygina, Moscow, 119991						
M. Fomicheva
Russian Research Center for Molecular Diagnostics and Therapy
														Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							8 Simferopol’sky bulv., Moscow, 117638						
V. Schvets
MIREA — Russian Technological University, Institute of Fine Chemical Technologies
														Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							78 prosp. Vernadskogo, Moscow, 119454						
A. Lobanov
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
														Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							4 ul. Kosygina, Moscow, 119991						
N. Yabbarov
Russian Research Center for Molecular Diagnostics and Therapy; N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
														Email: phaustova112@yandex.ru
				                					                																			                												                	Россия, 							8 Simferopol’sky bulv., Moscow, 117638; 4 ul. Kosygina, Moscow, 119991						
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