Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo


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Reactive oxygen species are generated by the redox reaction involving metalloporphyrin and ascorbic acid (AA) and lead to oxidative stress followed by cancer cell death. Polymer particles based on the copolymer of lactic and glycolic acid (PLGA) containing FeIIICl-tetraphenylporphyrin (FeClTPP) were prepared and characterized. These particles in combination with AA exhibit cytotoxic activity against the K562 (human chronic myelogenous leukemia) and MCF7 (human breast adenocarcinoma) cell lines. Results in vitro indicated significant antitumor efficiency on mice inoculated with P388 leukemic cells and treated with FeClTPP/AA. The cytotoxic activity of the combined system is achieved due to the formation of reactive oxygen species. The application of this system to the study of anticancer efficiency in vivo on the model of mice that were hypodermically inoculated with P388 lymphocytic leukemia revealed a significant inhibition of tumor growth. The use of FeClTPP in combination with AA seems to be promising in cancer treatment.

作者简介

M. Faustova

Russian Research Center for Molecular Diagnostics and Therapy; MIREA — Russian Technological University, Institute of Fine Chemical Technologies

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Email: phaustova112@yandex.ru
俄罗斯联邦, 8 Simferopol’sky bulv., Moscow, 117638; 78 prosp. Vernadskogo, Moscow, 119454

E. Nikolskaya

Russian Research Center for Molecular Diagnostics and Therapy; N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences

Email: phaustova112@yandex.ru
俄罗斯联邦, 8 Simferopol’sky bulv., Moscow, 117638; 4 ul. Kosygina, Moscow, 119991

M. Mollaev

MIREA — Russian Technological University, Institute of Fine Chemical Technologies

Email: phaustova112@yandex.ru
俄罗斯联邦, 78 prosp. Vernadskogo, Moscow, 119454

M. Sokol

Russian Research Center for Molecular Diagnostics and Therapy

Email: phaustova112@yandex.ru
俄罗斯联邦, 8 Simferopol’sky bulv., Moscow, 117638

A. Zabolotsky

Russian Research Center for Molecular Diagnostics and Therapy

Email: phaustova112@yandex.ru
俄罗斯联邦, 8 Simferopol’sky bulv., Moscow, 117638

O. Zhunina

Russian Research Center for Molecular Diagnostics and Therapy; N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences

Email: phaustova112@yandex.ru
俄罗斯联邦, 8 Simferopol’sky bulv., Moscow, 117638; 4 ul. Kosygina, Moscow, 119991

M. Fomicheva

Russian Research Center for Molecular Diagnostics and Therapy

Email: phaustova112@yandex.ru
俄罗斯联邦, 8 Simferopol’sky bulv., Moscow, 117638

V. Schvets

MIREA — Russian Technological University, Institute of Fine Chemical Technologies

Email: phaustova112@yandex.ru
俄罗斯联邦, 78 prosp. Vernadskogo, Moscow, 119454

A. Lobanov

N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences

Email: phaustova112@yandex.ru
俄罗斯联邦, 4 ul. Kosygina, Moscow, 119991

N. Yabbarov

Russian Research Center for Molecular Diagnostics and Therapy; N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences

Email: phaustova112@yandex.ru
俄罗斯联邦, 8 Simferopol’sky bulv., Moscow, 117638; 4 ul. Kosygina, Moscow, 119991

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