Bisdiamidophosphite with a bisoxazoline moiety in palladium-catalyzed enantioselective allylation


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A bisdiamidophosphite ligand with stereogenic phosphorus atoms as a part of 1,3,2-diaza-phospholidine rings and a bisoxazoline backbone was synthesized and studied in the Pd-catalyzed asymmetric allylic substitution. The use of this ligand provided up to 93% ee in the alkylation of (E)-1,3-diphenylallyl acetate with dimethyl malonate and up to 77% ee in the amination with pyrrolidine at quantitative conversion of the starting substrate.

Sobre autores

K. Gavrilov

S. A. Yesenin Ryazan State University

Autor responsável pela correspondência
Email: k.gavrilov@rsu.edu.ru
Rússia, 46 ul. Svobody, Ryazan, 390000

S. Zheglov

S. A. Yesenin Ryazan State University

Email: k.gavrilov@rsu.edu.ru
Rússia, 46 ul. Svobody, Ryazan, 390000

V. Gavrilov

S. A. Yesenin Ryazan State University

Email: k.gavrilov@rsu.edu.ru
Rússia, 46 ul. Svobody, Ryazan, 390000

I. Firsin

S. A. Yesenin Ryazan State University

Email: k.gavrilov@rsu.edu.ru
Rússia, 46 ul. Svobody, Ryazan, 390000

M. Maksimova

S. A. Yesenin Ryazan State University

Email: k.gavrilov@rsu.edu.ru
Rússia, 46 ul. Svobody, Ryazan, 390000

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