Отправить статью по E-mail Synthesis of dispirooxindoles containing N-unsubstituted heterocyclic moieties and study of their anticancer activity
- Авторы: Beloglazkina A.A.1, Karpov N.A.1, Mefedova S.R.1, Polyakov V.S.1, Skvortsov D.A.1, Kalinina M.A.1,2, Tafeenko V.A.1, Majouga A.G.1,3, Zyk N.V.1, Beloglazkina E.K.1
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Учреждения:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Skolkovo Institute of Science and Technology, Territory of the Skolkovo Innovation Center
- D. Mendeleev University of Chemical Technology of Russia
- Выпуск: Том 68, № 5 (2019)
- Страницы: 1006-1013
- Раздел: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243372
- DOI: https://doi.org/10.1007/s11172-019-2511-6
- ID: 243372
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Аннотация
A convenient method is proposed for the synthesis of N-unsubstituted spiroxindoles with different heterocyclic moieties (2-thiohydantoin, hydantoin, and thiazolidine) by the regio-selective 1,3-dipolar cycloaddition of azomethine ylides, generated from isatins and sarcosine, to arylidene derivatives of corresponding heterocycles. The cytotoxicity of compounds was tested by the MTT method against MCF7, A549, HEK, and VA13 cell lines and compared with the anticancer drug Nutlin-3a. The best bioactivity was observed for hydantoin-based dispiroindolinones, the most cytotoxic compound demonstrated selectivity against A549 lung cancer cells with an IC50 value of 6.6±1.6 μmol L−1.
Об авторах
A. Beloglazkina
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191
N. Karpov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191
S. Mefedova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191
V. Polyakov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191
D. Skvortsov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191
M. Kalinina
Department of Chemistry, M. V. Lomonosov Moscow State University; Skolkovo Institute of Science and Technology, Territory of the Skolkovo Innovation Center
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191; 1 Build., 30 Bolshoi bul’var, Moscow, 121205
V. Tafeenko
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191
A. Majouga
Department of Chemistry, M. V. Lomonosov Moscow State University; D. Mendeleev University of Chemical Technology of Russia
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191; 9 Miusskaya pl., Moscow, 125047
N. Zyk
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191
E. Beloglazkina
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: izvan@ioc.ac.ru
Россия, 3 Build., 1 Leninskie Gory, Moscow, 119191
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