Synthesis, characterization, and antileukemic activity of new water-soluble analogs of prodimin
- Authors: Goncharova S.A.1, Yakushchenko I.K.1, Raevskaya T.A.1, Yakushchenko T.N.1, Konovalova N.P.1
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Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Issue: Vol 68, No 1 (2019)
- Pages: 181-185
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243296
- DOI: https://doi.org/10.1007/s11172-019-2435-1
- ID: 243296
Cite item
Abstract
Two new compounds from the class of bis(3-halopropionyl)amides were synthesized by the reaction of 3-halopropionyl chloride with N,N′-dimethylethylenediamine. These structural analogs of prodimin, a water insoluble anticancer drug, are soluble in water, which significantly expands methods for their administration into a body. The compounds obtained and prodimin (as a reference substance) were studied on P388 murine leukemia and some of its drug-resistant strains. The data obtained suggest a high efficacy of one synthesized compound against drug-resistant tumors.
About the authors
S. A. Goncharova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: sago@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
I. K. Yakushchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sago@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
T. A. Raevskaya
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sago@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
T. N. Yakushchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sago@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
N. P. Konovalova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sago@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432