Synthesis, properties, and antianemic activity of new metal complexes of sodium pectinate with iron and calcium
- Authors: Minzanova S.T.1, Mironov V.F.1, Mironova L.G.1, Nemtarev A.V.1, Vyshtakalyuk A.B.1, Kholin K.V.1, Nizameeva G.R.2, Milyukov V.A.1
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Affiliations:
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
- Kazan National Research Technological University
- Issue: Vol 68, No 1 (2019)
- Pages: 48-54
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243275
- DOI: https://doi.org/10.1007/s11172-019-2414-6
- ID: 243275
Cite item
Abstract
A new water-soluble complex based on sodium pectinate with iron and calcium (P-NaFeCa) was synthesized. The regularities of the complexation of sodium pectinate (with a 35% content of COONa groups) with biogenic metals Ca and Fe were studied. The content of macro- and microelements was determined by atomic emission spectrometry; the product was identified by IR spectroscopy. Using atomic force microscopy, it was found that the average particle size of P-NaFeCa is ~170 nm. The efficiency of P-NaFeCa (per os) was studied for the first time in animals with hemolytic anemia modeled by administration of phenylhydrazine. It was experimentally shown that in vivo P-NaCaFe at a dose of 60 mg kg–1 containing 50% of the recommended therapeutic dose of iron helps to recover the number of erythrocytes and mean concentration hemoglobin in erythrocyte, which indicates the efficiency of P-NaCaFe as an agent restoring the blood parameters after exposure to hemolytic poisons.
About the authors
S. T. Minzanova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Author for correspondence.
Email: minzanova@iopc.ru
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
V. F. Mironov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: minzanova@iopc.ru
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
L. G. Mironova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: minzanova@iopc.ru
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
A. V. Nemtarev
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: minzanova@iopc.ru
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
A. B. Vyshtakalyuk
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: minzanova@iopc.ru
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
K. V. Kholin
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: minzanova@iopc.ru
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
G. R. Nizameeva
Kazan National Research Technological University
Email: minzanova@iopc.ru
Russian Federation, 68 ul. K. Marksa, Kazan, 420015
V. A. Milyukov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: minzanova@iopc.ru
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088