Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)
- 作者: Tsebrikova G.S.1, Barsamian R.T.2, Solov´ev V.P.1, Kudryashova Z.A.1,2, Baulin V.E.1,3, Wang Y.J.4, Tsivadze A.Y.1
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隶属关系:
- Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
- Russian Technological University, Lomonosov Moscow State University of Fine Chemical Technologies
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- School of Materials Science and Engineering, Harbin Institute of Technology
- 期: 卷 67, 编号 12 (2018)
- 页面: 2184-2187
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243213
- DOI: https://doi.org/10.1007/s11172-018-2352-8
- ID: 243213
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详细
Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H8L) were determined for the first time by potentiometric titration in water using the CHEMEQUI program. The stability constants of Ga3+ complexes with deprotonated forms of DOTMP were determined. The stability constant of the Ga3+ complex with the fully deprotonated DOTMP ligand, lg KML equal to 27.8, is higher than the corresponding constant for the Ga3+ complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the ligand most widely used in radiopharmacy; it is also higher than the constant for the Ga3+ complex with plasma protein transferrin, which makes the DOTMP ligand very promising for the use in radiopharmacy.
作者简介
G. Tsebrikova
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: tsebrikova@yandex.ru
俄罗斯联邦, Build. 4, 31 Leninsky prosp., Moscow, 119071
R. Barsamian
Russian Technological University, Lomonosov Moscow State University of Fine Chemical Technologies
Email: tsebrikova@yandex.ru
俄罗斯联邦, 78 prosp. Vernadskogo, Moscow, 119454
V. Solov´ev
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
俄罗斯联邦, Build. 4, 31 Leninsky prosp., Moscow, 119071
Z. Kudryashova
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences; Russian Technological University, Lomonosov Moscow State University of Fine Chemical Technologies
Email: tsebrikova@yandex.ru
俄罗斯联邦, Build. 4, 31 Leninsky prosp., Moscow, 119071; 78 prosp. Vernadskogo, Moscow, 119454
V. Baulin
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences; Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
俄罗斯联邦, Build. 4, 31 Leninsky prosp., Moscow, 119071; 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
Y. Wang
School of Materials Science and Engineering, Harbin Institute of Technology
Email: tsebrikova@yandex.ru
中国, 92 West Dashi st., Harbin, 150001
A. Tsivadze
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: tsebrikova@yandex.ru
俄罗斯联邦, Build. 4, 31 Leninsky prosp., Moscow, 119071
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